Reggie was destined for greatness when he became the most highly-recruited running back out of high school, but not even he could have predicted what was to come. At USC, Reggie was a two-time All-American first-team pick, and in 2005 also claimed the Associated Press Player of the Year, Doak Walker (best running back), Walter Camp and Heisman Trophy (both player of the year) awards.
New Orleans Saints acted quickly to secure his services at number two in the 2006 NFL draft and Bush repaid them with a fine first season in which he equalled the club’s single game record with four touchdowns against the San Francisco 49ers.
In 2008, Reggie also achieved wider-spread fame by tying the NFL record of returning two punts for touchdowns in one half against Minnesota. A knee injury cut short that season but he vowed to come back stronger than ever on his return, and helped the Saints to a Super Bowl championship title at the end of the '09 season.
In 2011, the Saints traded Reggie to the Miami Dolphins.